UNC3474
Product Specifications
CAS Number
1648707-79-2
Target
Others|||MDM-2/p53
Related Pathways
Apoptosis|||Others
Bioactivity
UNC3474, a small molecule ligand, selectively interacts with the aromatic methyl-lysine binding cage of the tumor protein 53BP1 Tudor domain (TT), exhibiting a dissociation constant (Kd) of 1.0±0.3 ?M. It impedes 53BP1's recruitment to DNA double-strand breaks (DSBs), maintaining the protein's autoinhibited state within cells [1].
Smiles
O=C(NCCCNC(C)(C)C)C1=CC=CC(=C1)C(C)C
Molecular Formula
C17H28N2O
Molecular Weight
276.42
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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