YN14
Product Specifications
Target
Ras, PROTACs, Kras
Related Pathways
PROTAC, MAPK, GPCR/G Protein
Bioactivity
YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (ΔG) . It exhibits antiproliferative effects, significantly inhibiting the growth of KRASG12C-mutant cancer cells, and demonstrates tumor regression with tumor growth inhibition (TGI%) rates exceeding 100% in the MIA PaCa-2 xenograft model.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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