YN14
Product Specifications
Target
Ras, PROTACs, Kras
Related Pathways
PROTAC, MAPK, GPCR/G Protein
Bioactivity
YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (ΔG) . It exhibits antiproliferative effects, significantly inhibiting the growth of KRASG12C-mutant cancer cells, and demonstrates tumor regression with tumor growth inhibition (TGI%) rates exceeding 100% in the MIA PaCa-2 xenograft model.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
033114-ML405 100 µL
CA6, CT (CA6, Carbonic anhydrase 6, Carbonate dehydratase VI, Carbonic anhydrase VI, Salivary carbonic anhydrase, Secreted carbonic anhydrase) (MaxLight 405) discontinued
Sign In for Pricing
View Details 
GTR15090563 1 Vial
Lentiviral human NEIL1 shRNA (UAS) - Lentiviral human NEIL1 shRNA (UAS, RFP) (25)
Sign In for Pricing
View Details