β-Glucuronide-NB-bis[N (Me) -methyl ester]-MMAE
Product Specifications
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
β-Glucuronide-NB-bis[N (Me) -methyl ester]-MMAE (compound 20), an auristatins-glucuronide conjugate, exhibits in vitro antiproliferative effects on cancer cells, both β-glucuronidase pretreated and untreated, with an IC50 range of 5.7 nM to 9.7 nM. Demonstrating powerful antitumor efficacy in an HCT-116 xenograft mouse model, this compound does not induce side effects [1].
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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