γ-Fibrinogen 377-395

Product Specifications

CAS Number

957792-67-5

Bioactivity

?-Fibrinogen377-395 is a peptide derived from fibrinogen, functioning both as an inhibitory molecule and an epitope. It inhibits microglial activation, disrupts fibrin-Mac-1 interactions in vitro, and mitigates experimental autoimmune encephalomyelitis (EAE) in murine models in vivo. This compound is relevant for research into multiple sclerosis (MS) and other neuroinflammatory disorders characterized by blood-brain barrier compromise and microglial activation [1].

Smiles

C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)N)=O)CO)=O)CCSC)=O)CCCCN)=O)CCC(O)=O)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)CCSC)=O)CCCCN)=O)[C@H](CC)C)=O)[C@H](CC)C)(=O)N2[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(O)=O)=O)[C@H](CC)C)=O)CO)=O)CC(C)C)=O)CCCNC(=N)N)=O)CC(N)=O)=O)=O)CCC2