Thalidomide-NH- (CH2) 2-NH2 TFA
Product Specifications
CAS Number
1957235-67-4
Target
E3 Ligase Ligand-Linker Conjugate, Others, Autophagy, Apoptosis
Related Pathways
Autophagy, PROTAC, Others, Apoptosis
Bioactivity
Thalidomide-NH- (CH2) 2-NH2 TFA, an alkyl-modified derivative of Thalidomide, functions as a Cereblon ligand to recruit CRBN proteins and serves as a crucial intermediate in the synthesis of CRBN-based PROTAC molecules targeting the SHP2 protein.
Smiles
NCCNC1=C2C(=O)N(C3C(=O)NC(=O)CC3)C(=O)C2=CC=C1.OC(=O)C(F)(F)F
Molecular Formula
C17H17F3N4O6
Molecular Weight
430.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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