Cinrebafusp alfa
Product Specifications
CAS Number
2218515-90-1
Target
EGFR, TNF
Related Pathways
JAK/STAT signaling, Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
Cinrebafusp alfa (PRS 343) is an anticalin-based bispecific drug with high affinity for both CD137/HER2, displaying dissociation constants (Kd) of 0.3 nM to recombinant human HER2 and 5 nM to human monomeric CD137 (4-1BB) . It promotes T-cell costimulation via tumor-localized, HER2-mediated 4-1BB clustering and activation, thereby enhancing T-cell receptor-driven responses and facilitating tumor cell eradication. This compound shows promising potential in research concerning HER2-positive solid tumors [1] [2].
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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