Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
Product Specifications
CAS Number
211190-38-4
Target
Protease-activated Receptor
Related Pathways
GPCR/G Protein
Bioactivity
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1) [a subtype of G-protein coupled receptors involved in mediating thrombin's cellular effects]. Exhibiting high specificity for PAR-1 over PAR-2, its selectivity was assessed via cell-based calcium signaling assays in HEK293 cells. As an agonist, it is instrumental for in vivo investigations of PAR-1 activation. PAR-1 also collaborates with PAR-4, influencing thrombin-induced hepatocellular carcinoma within [coagulation type] tumor environments where thrombin generation occurs.
Smiles
[C@@H](CC1CCCCC1)(NC([C@@H](NC([C@H](CC2=CC=C(F)C=C2)NC([C@H](C)N)=O)=O)CCCNC(=N)N)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N)=O)=O)CCCNC(N)=O)=O
Molecular Formula
C42H63FN12O8
Molecular Weight
883.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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