Garvicin KS, GakC

Garvicin KS is a 32-amino-acid peptide that, in collaboration with two other peptides, GakA and GakB, constitutes the bacteriocin GarKS. This compound impairs fibroblast viability and proliferation and exhibits antimicrobial activity against MSSA, demonstrating minimum inhibitory concentration (MIC) values ranked as GakB > GakC > GakA [1].

C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(NCC(NCC(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)CC(C)C)=O)CCCCN)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)NC([C@@H](NC(CNC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CCSC)N)=O)=O)C)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCCCN)=O)C)=O)=O)C)=O)CCCCN)=O)[C@H](CC)C)=O)C(C)C)=O)=O)CCCCN)=O)=O)C)=O)CC(C)C)=O)[C@@H](C)O)=O)=O)=O)=O)C(C)C)=O)C=2C=3C(NC2)=CC=CC3