Garvicin KS, GakB

Garvicin KS (GarKS) is a bacteriocin comprising a 34-amino-acid peptide, GakB, along with two additional peptides, GakA and GakC. GakB specifically impairs fibroblast viability and proliferation. When combined with GakA, GarKS demonstrates enhanced peptide stability, antimicrobial activity, and notable impacts on fibroblast viability and proliferation. Regarding methicillin-sensitive Staphylococcus aureus (MSSA) inhibition, minimum inhibitory concentration (MIC) values rank the peptides in descending order of effectiveness as GakB, followed by GakC, and then GakA [1].

[C@@H](CC1=CC=C(O)C=C1)(NC([C@@H](NC([C@@H](NC(CNC(CNC([C@@H](NC([C@@H](NC(CNC(CNC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CCSC)N)=O)=O)C)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCCCN)=O)C)=O)=O)C)=O)CCCCN)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)=O)CCCCN)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)C)=O)C)=O)=O)=O)C)=O)[C@@H](C)O)=O)C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(NCC(O)=O)=O)=O)[C@H](CC)C)=O)CCCCN)=O)CCCCN)=O)CC(C)C)=O)=O)=O