Maurotoxin

Maurotoxin, a 34-residue peptide featuring four disulfide bridges, is extracted from the chactoid scorpion (Scorpio maurus) and known to impede Shaker potassium channels (ShB) K+ flow, exhibiting an IC50 of 2 nM [1] [2].

O=C1N2[C@@](CCC2)(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]3(C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(N[C@H](C(N[C@@H]4C(=O)N[C@@H](CC5=CC=C(O)C=C5)C(=O)NCC(=O)N[C@H](C(N)=O)CSSC4)=O)CCCCN)=O)CSSC[C@@](C(=O)N[C@@H](CC6=CC=C(O)C=C6)C(=O)N[C@@H](C)C(=O)N7[C@](C(=O)N[C@]8(CSSC[C@@]1(NC(=O)CNC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC8=O)[H])[H])[H])(CCC7)[H])(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@]([C@@H](C)O)(NC(=O)[C@@H](NC([C@@H](NC([C@H](C(C)C)N)=O)CO)=O)CSSC3)[H])[H])[H])[H])[H]