αC-Conotoxin PrXA

?C-Conotoxin PrXA is a neurotoxic paralytic peptide acting as a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting inhibitory constants (IC50) of 1.8 nM for the adult ?1?1?? subtype and 3.0 nM for the fetal ?1?1?? subtype. The compound vies with ?-bungarotoxin for binding sites at the ?/? and ?/? interfaces of neuromuscular nAChRs, demonstrating high selectivity[1].