Aloenin aglycone
Product Specifications
CAS Number
59163-53-0
Target
NO Synthase, Others, NF-κB
Related Pathways
Immunology/Inflammation, NF-κB, Others
Bioactivity
Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate. It impedes TNFα-stimulated NF-κB transcriptional activity, showing an IC 50 of 18.7 μM. At a concentration of 10 μM, aloenin aglycone decreases both inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression in HepG2 cells exposed to 10 ng/mL TNFα [1].
Smiles
CC1=C(C(O)=CC(O)=C1)C2=CC(OC)=CC(=O)O2
Molecular Formula
C13H12O5
Molecular Weight
248.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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