Aloenin aglycone
Product Specifications
CAS Number
59163-53-0
Target
NO Synthase|||Others|||NF-?B
Related Pathways
Immunology/Inflammation|||NF-?B|||Others
Bioactivity
Aloenin aglycone (compound 13), an inhibitor of NF-?B, can be sourced from aloe exudate. It impedes TNF?-stimulated NF-?B transcriptional activity, showing an IC 50 of 18.7 ?M. At a concentration of 10 ?M, aloenin aglycone decreases both inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression in HepG2 cells exposed to 10 ng/mL TNF? [1].
Smiles
CC1=C(C(O)=CC(O)=C1)C2=CC(OC)=CC(=O)O2
Molecular Formula
C13H12O5
Molecular Weight
248.23
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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