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RMC-4998

Product Specifications

CAS Number

2642037-07-6

Target

PI3K, Kras, ERK, mTOR, Ras, Apoptosis

Related Pathways

GPCR/G Protein, MAPK, Apoptosis, PI3K/Akt/mTOR signaling

Purity

0.9911

Bioactivity

RMC-4998 is an orally available KRASG12C mutant inhibitor that targets the active or GTP-bound state of the KRASG12C mutant and binds to intracellular CYPA to form a triple complex to inhibit the ERK signaling pathway and induce apoptosis, which is of great significance for tumor research.

Smiles

O=C(N1CC[C@@]2(C1)C(N(C(C(C)C)C(NC3C(N4N[C@@H](CCC4)C(OCC(C)(CC5=C(C6=C([C@@H](C)OC)N=CC=C6)N(CC)C7=CC=C(C8=CC(C3)=CC=C8)C=C57)C)=O)=O)=O)CC2)=O)C#CC(C)(C)N(C)C

Molecular Formula

C57H74N8O7

Molecular Weight

983.25

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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