RMC-4998
Product Specifications
CAS Number
2642037-07-6
Target
PI3K|||Kras|||ERK|||mTOR|||Ras|||Apoptosis
Related Pathways
GPCR/G Protein|||MAPK|||Apoptosis|||PI3K/Akt/mTOR signaling
Purity
0.9911
Bioactivity
RMC-4998 is an orally available KRASG12C mutant inhibitor that targets the active or GTP-bound state of the KRASG12C mutant and binds to intracellular CYPA to form a triple complex to inhibit the ERK signaling pathway and induce apoptosis, which is of great significance for tumor research.
Smiles
O=C(N1CC[C@@]2(C1)C(N(C(C(C)C)C(NC3C(N4N[C@@H](CCC4)C(OCC(C)(CC5=C(C6=C([C@@H](C)OC)N=CC=C6)N(CC)C7=CC=C(C8=CC(C3)=CC=C8)C=C57)C)=O)=O)=O)CC2)=O)C#CC(C)(C)N(C)C
Molecular Formula
C57H74N8O7
Molecular Weight
983.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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