ROCK-IN-9
Product Specifications
CAS Number
2643334-76-1
Target
ROCK
Related Pathways
Cytoskeletal Signaling, Stem Cells, Cell Cycle/Checkpoint
Bioactivity
ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM. It demonstrates favorable pharmacokinetic properties in mice, achieving high in vivo exposure and oral bioavailability at low doses [1].
Smiles
C(NCC1=CC(OC)=CC=C1)(=O)N2C=3C(=CC(=C(F)C3)C=4C(N)=NNC4)CC2
Molecular Formula
C20H20FN5O2
Molecular Weight
381.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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