PHD-IN-1
Product Specifications
CAS Number
2924182-31-8
Target
HIF/HIF Prolyl-Hydroxylase
Related Pathways
Metabolism, Chromatin/Epigenetic
Bioactivity
PHD-IN-1 (compound 80) is a potent PHD2 inhibitor with an IC50 value of ≤5 nM and demonstrates EC50 values of 2.5 μM in EPO Elisa assays in both Caco2-HIF1a-HiBiT-clone-1 and Hep3B cell lines [1].
Smiles
OC=1C2=C(N=C(N3[C@@]4(CN([C@](C3)(C4)[H])C5CC5)[H])C=C2)C=NC1C(NCC=6C=CC(C#N)=NC6)=O
Molecular Formula
C24H23N7O2
Molecular Weight
441.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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