EGFR-IN-89
Product Specifications
CAS Number
2413029-40-8
Target
EGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Bioactivity
EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor that selectively targets EGFR mutations, showing potent activity with an IC50 of 10.1 nM against Del19/T790M/C797S mutations, and demonstrating greater selectivity for mutant forms over wild type [1].
Smiles
N(C1=C2C(=NC(NC3=CC(F)=C(C=C3)N4CCN(CC)CC4)=N1)NC=C2)C5=C(N(S(C)(=O)=O)C)C=CC=C5
Molecular Formula
C26H31FN8O2S
Molecular Weight
538.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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