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JNK-IN-14

Product Specifications

Target

JNK|||Cytochromes P450

Related Pathways

Metabolism|||MAPK

Bioactivity

JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3. It induces early-stage apoptosis, arrests cell population at the G2/M phase, and moderately inhibits beclin-1 production in K562 leukemia cells, demonstrating greater inhibitory efficacy than SP600125. [1]

Molecular Formula

C27H31N5O4S

Molecular Weight

521.63

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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