IDH2R140Q-IN-2
Product Specifications
CAS Number
2749568-16-7
Target
Dehydrogenase, Isocitrate Dehydrogenase (IDH)
Related Pathways
Metabolism
Purity
0.9992
Bioactivity
IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation (IC50 of 10 nM) and inhibiting tumour tissue D2HG levels.IDH2R140Q-IN-2 is suitable for the study of acute myeloid leukaemia (AML) .
Smiles
FC(F)(F)C=1C=CC=C(C1)NC=2N=C(N=C(N2)N3CCC(O)C3)NC4=CC=CC(=C4)C(F)(F)F
Molecular Formula
C21H18F6N6O
Molecular Weight
484.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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