Caspase-3 activator 1
Product Specifications
Target
Pyroptosis
Related Pathways
Apoptosis|||Immunology/Inflammation
Bioactivity
Caspase-3 activator 1 (compound 4b), a Ru (III) metal complex, effectively inhibits gastric tumor growth and metastasis by mediating caspase-3 cleavage, enabling Caspase-3 to process gasdermin E (GSDME), resulting in GSDME-N terminus production and perforation of the gastric tumor cell membrane. Furthermore, compound 4b induces pyroptosis and subsequent immune responses and can be incorporated with decitabine (DCT) into the 4b-DCT-Lip lipid delivery system [1].
Molecular Formula
C28H27N6O2RuS2
Molecular Weight
644.75
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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