CARM1 degrader-2

PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated arginine methyltransferase (CARM1) . It promotes the degradation of CARM1 and prevents the methylation of its substrates, including poly (A) -binding protein PABP1 and BGR1-associated factor BAF155, consequently inhibiting breast cancer cell migration [1].