CARM1 degrader-1

PROTAC CARM1 degrader-1 (compound 3b) is a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1), facilitating its degradation via the VHL-proteasome pathway. By degrading CARM1, it reduces methylation of substrates, such as poly (A) -binding protein PABP1 and BGR1-associated factor BAF155, inhibiting breast cancer cell migration [1].