NLRP3-IN-20
Product Specifications
CAS Number
2428478-22-0
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Bioactivity
NLRP3-IN-20 (compound 11) is an orally administered inhibitor targeting the NLRP3 inflammasome, exhibiting potent inhibition with an IC50 of 25 nM against IL-1β secretion. It possesses excellent pharmacokinetic properties and has shown significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis [1].
Smiles
N(C(NS(=O)(=O)C1=CC=C(CN(C)C)C=C1)=O)C2=C3C(=CC4=C2CCC4)CCC3
Molecular Formula
C22H27N3O3S
Molecular Weight
413.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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