MLKL-IN-6
Product Specifications
Target
Necroptosis, MLK
Related Pathways
Apoptosis, MAPK
Bioactivity
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are critical steps in cell necrosis. Additionally, MLKL-IN-6 restrains immune cell death, diminishes adhesion factor expression, exhibits low cytotoxicity, impedes hepatic stellate cell activation, decreases liver fibrosis marker levels, and exerts anti-fibrotic effects [1].
Smiles
OC1=CC(C#CCN2C(N=C(/C=C/C(OC)=O)N3C)=C3C(N(C)C2=O)=O)=CC=C1
Molecular Formula
C20H18N4O5
Molecular Weight
394.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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