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LB244

Product Specifications

Target

STING

Related Pathways

Immunology/Inflammation

Bioactivity

LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1].

Smiles

O=C(N[C@@H](CCCCNC(C1=CC=C([N+]([O-])=O)O1)=O)C2=NC(C=CC=C3)=C3N2)C(C=C4)=CC=C4C5=CC=CC=C5

Molecular Formula

C30H27N5O5

Molecular Weight

537.57

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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