VHL-IN-1
Product Specifications
Target
Ligand for E3 Ligase, HIF/HIF Prolyl-Hydroxylase
Related Pathways
Metabolism, PROTAC, Chromatin/Epigenetic
Bioactivity
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and enhances its transcriptional activity. It shows promise for applications as a HIF-1α stabilizer and for the degradation of proteolytically targeted chimeras (PROTACs) [1].
Molecular Formula
C28H37FN4O4S
Molecular Weight
544.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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