CaMKII?-PHOTAC
Product Specifications
Target
CaMK|||PROTACs
Related Pathways
PROTAC|||Neuroscience
Bioactivity
CaMKII?-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II ? (CaMKII?), facilitating its ubiquitination and subsequent proteasome-mediated degradation when exposed to specific light wavelengths. Under illumination, CaMKII?-PHOTAC diminishes synaptic functions and weakens evoked field excitatory postsynaptic potentials in the mouse hippocampus, impacting physiological responses and sustaining long-term potentiation and memory functions within dendritic domains [1].
Molecular Formula
C54H58Cl2N10O11
Molecular Weight
1094
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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