PI3Kα/HDAC6-IN-1
Product Specifications
Target
PI3K, HDAC
Related Pathways
PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, with IC50 values of 2.9 nM and 26 nM, respectively. It hinders AKT (Ser473) phosphorylation and promotes the accumulation of acetylated α-tubulin without affecting acetylated histones H3 and H4. The compound exhibits potent anti-cancer efficacy, inhibiting the L-363 cell line with an IC50 of 0.17 μM [1].
Molecular Formula
C27H30F3N7O6S2
Molecular Weight
669.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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