Paluratide
Product Specifications
CAS Number
2676177-63-0
Target
Kras|||ERK|||Ras|||Akt
Related Pathways
GPCR/G Protein|||MAPK|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling
Purity
0.987
Bioactivity
Paluratide (LUNA18) is a reversible cyclic peptide KRAS inhibitor with the advantages of oral availability and cell permeability for the treatment of kras-mutant cancers, which inhibits cancer cell proliferation by phosphorylating ERK and AKT, and also inhibits the interaction of RAS with guanine nucleotide exchange factors (GEFs) .
Smiles
O=C1C2(NC(=O)[C@]3(N(C(=O)[C@H](CCC4=CC(F)=C(C(F)(F)F)C(F)=C4)NC(=O)CN(C)C(=O)[C@H](CC5=CC=C(C)C=C5)N(CC)C(=O)[C@]6(N(C(=O)[C@H](C)N(C)C(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](CC(C)C)N(C)C(=O)C[C@@H](C(N(C)C)=O)N(C)C(=O)[C@@H](N1C)C7CCCC7)[H])CC6)[H])CCC3)[H])CCCC2
Molecular Formula
C73H105F5N12O12
Molecular Weight
1437.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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