MeOIstPyrd
Product Specifications
CAS Number
2308548-54-9
Target
Others, MDM-2/p53
Related Pathways
Others, Apoptosis
Bioactivity
MeOIstPyrd is an anti-skin cancer agent that inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. It induces DNA damage, activates p53, increases its half-life, and stabilizes p53 via ser15 phosphorylation. Additionally, MeOIstPyrd interfaces with MDM2 within the p53 sub-pocket, preventing the p53-MDM2 interaction [1].
Smiles
N(\NC(=S)N1CCCC1)=C\2/C=3C(NC2=O)=CC=C(OC)C3
Molecular Formula
C14H16N4O2S
Molecular Weight
304.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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