Lepadin E
Product Specifications
CAS Number
444914-19-6
Target
Glutathione Peroxidase|||MDM-2/p53|||Ferroptosis
Related Pathways
Apoptosis|||Metabolism
Bioactivity
Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway. By elevating p53 and repressing SLC7A11 and GPX4 expression, it heightens ROS and lipid peroxidation while also augmenting ACSL4 expression, culminating in cell death. This compound exhibits a considerable antitumor effect [1].
Smiles
C(CCC[C@@H](CCC)O)[C@@H]1[C@]2([C@](N[C@@H](C)[C@H](OC(/C=C/CCCCC)=O)C2)(CCC1)[H])[H]
Molecular Formula
C26H47NO3
Molecular Weight
421.66
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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