Lepadin E
Product Specifications
CAS Number
444914-19-6
Target
Glutathione Peroxidase, MDM-2/p53, Ferroptosis
Related Pathways
Apoptosis, Metabolism
Bioactivity
Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway. By elevating p53 and repressing SLC7A11 and GPX4 expression, it heightens ROS and lipid peroxidation while also augmenting ACSL4 expression, culminating in cell death. This compound exhibits a considerable antitumor effect [1].
Smiles
C(CCC[C@@H](CCC)O)[C@@H]1[C@]2([C@](N[C@@H](C)[C@H](OC(/C=C/CCCCC)=O)C2)(CCC1)[H])[H]
Molecular Formula
C26H47NO3
Molecular Weight
421.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS9518666-01 1 Kit
CD79A (Phospho-Tyr182) Colorimetric Cell-Based ELISA Kit
Sign In for Pricing
View Details MBS9518666-02 5x 1 Kit
CD79A (Phospho-Tyr182) Colorimetric Cell-Based ELISA Kit
Sign In for Pricing
View Details 
![Rabbit Polyclonal LIFR alpha Antibody [DyLight 350]](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
NBP2-32070UV 0.1 mL
Rabbit Polyclonal LIFR alpha Antibody [DyLight 350]
Sign In for Pricing
View Details 
MBS1164620-01 0.5 mg (E-Coli)
Recombinant Coxiella burnetii UvrABC system protein B (uvrB)
Sign In for Pricing
View Details