LYP-IN-4
Product Specifications
Target
Phosphatase
Related Pathways
Metabolism
Bioactivity
LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 μM, IC50=3.52μM), regulates TCR signaling, increases PD-1/PD-L1 expression, and strengthens anti-tumor immunity. It also stimulates T cell activation, impedes M2 macrophage polarization, and suppresses tumor progression in MC38 isogenic mouse models.
Molecular Formula
C29H21ClN2O8S
Molecular Weight
593
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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