Anti-inflammatory agent 54
Product Specifications
CAS Number
2924156-46-5
Target
NF-?B|||Others|||Interleukin|||NO Synthase|||TNF
Related Pathways
Apoptosis|||NF-?B|||Others|||Immunology/Inflammation
Bioactivity
Anti-inflammatory agent 54 (compound 9c), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-?B pathway and reducing the expression of pro-inflammatory cytokines such as iNOS, TNF-?, IL-6, and IL-1?. It effectively suppresses LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 of 2.4 ?M and demonstrates in vivo efficacy in a mouse auricular edema model [1].
Smiles
C(CNC(/C=C/C1=CC=CO1)=O)N2C=3C(OC2=O)=CC(OC)=CC3
Molecular Formula
C17H16N2O5
Molecular Weight
328.32
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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