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PARP1-IN-14

Product Specifications

CAS Number

2098639-70-2

Target

PARP, Apoptosis

Related Pathways

Chromatin/Epigenetic, DNA Damage/DNA Repair, Apoptosis

Bioactivity

PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor with an IC50 of 0.6 ± 0.1 nM, displaying antiproliferative effects on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with IC50 values below 0.3 nM [1].

Smiles

CC1N2C(=NN=C2CN(C(=O)C3=CC(CC=4C=5C(C(=O)NN4)=CC=CC5)=CC=C3F)C1)C=6N=C(OC)C=CC6

Molecular Formula

C28H24FN7O3

Molecular Weight

525.53

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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