What is the catalog number for Sirt1/2-IN-3?

The catalog number for Sirt1/2-IN-3 is T79564.

What sizes are available for Sirt1/2-IN-3?

Sirt1/2-IN-3 is available in the following size(s): 5 mg, 50 mg.

How many pack sizes does Sirt1/2-IN-3 come in?

Sirt1/2-IN-3 is available in 2 different pack sizes.

Is Sirt1/2-IN-3 in stock?

Sirt1/2-IN-3 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Sirt1/2-IN-3?

Sirt1/2-IN-3 is manufactured by Molfinity.

What is the estimated delivery time for Sirt1/2-IN-3?

Estimated delivery time for Sirt1/2-IN-3 is approximately 10 business day(s), depending on your location.

Sirt1/2-IN-3

Product Specifications

CAS Number

301313-42-8

Target

Sirtuin, Apoptosis

Related Pathways

Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair

Bioactivity

Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively. This compound effectively inhibits p53 deacetylation while simultaneously elevating p53 and α-tubulin acetylation levels. Additionally, Sirt1/2-IN-3 promotes apoptosis and exhibits antiproliferative effects on human leukemia cell lines [1].