Sirt1/2-IN-2
Product Specifications
CAS Number
670267-73-9
Target
Apoptosis, Sirtuin
Related Pathways
Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor, targeting SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin, promoting apoptosis and exhibiting anti-proliferative effects on human leukemia cell lines [1].
Smiles
N(S(=O)(=O)C1=CC=CC=C1)C=2C3=C(C(O)=C(SC=4NC=NN4)C2)C=CC=C3
Molecular Formula
C18H14N4O3S2
Molecular Weight
398.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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