What is the catalog number for 22- (4′-py) -JA?

The catalog number for 22- (4′-py) -JA is T79560.

What sizes are available for 22- (4′-py) -JA?

22- (4′-py) -JA is available in the following size(s): 5 mg, 50 mg.

How many pack sizes does 22- (4′-py) -JA come in?

22- (4′-py) -JA is available in 2 different pack sizes.

Is 22- (4′-py) -JA in stock?

22- (4′-py) -JA is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures 22- (4′-py) -JA?

22- (4′-py) -JA is manufactured by Molfinity.

What is the estimated delivery time for 22- (4′-py) -JA?

Estimated delivery time for 22- (4′-py) -JA is approximately 10 business day(s), depending on your location.

22- (4′-py) -JA

Product Specifications

CAS Number

1178895-15-2

Target

Akt, mTOR

Related Pathways

Cytoskeletal Signaling, PI3K/Akt/mTOR signaling

Bioactivity

22- (4′-py) -JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumor cell invasion and angiogenesis in human umbilical vein endothelial cells (HUVEC), while suppressing the expression of metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF) . Its potent anticancer activity is particularly noted against non-small cell lung cancer (NSCLC) [1].