22- (4′-py) -JA
Product Specifications
CAS Number
1178895-15-2
Target
Akt, mTOR
Related Pathways
Cytoskeletal Signaling, PI3K/Akt/mTOR signaling
Bioactivity
22- (4′-py) -JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumor cell invasion and angiogenesis in human umbilical vein endothelial cells (HUVEC), while suppressing the expression of metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF) . Its potent anticancer activity is particularly noted against non-small cell lung cancer (NSCLC) [1].
Smiles
C(OC(=O)C=1C=CN=CC1)[C@@H]2N3[C@]([C@]4(C5=C(C[C@@]([C@@H]3C#N)(N4C)[H])C(=O)C(C)=C(OC)C5=O)[H])(CC6=C2C(=O)C(OC)=C(C)C6=O)[H]
Molecular Formula
C32H30N4O8
Molecular Weight
598.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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