Fac-[Re (CO) 3 (L3) (H2O) ][NO3]

Fac-[Re (CO) 3 (L3) (H2O) ][NO3] (Compound 3), a rhenium (I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction. It exhibits cytotoxicity against prostate cancer cells, demonstrating an IC50 value of 0.32 μM in PC-3 cells. This compound predominantly localizes to the mitochondria, reducing ATP production and triggering paraptosis in PC3 cells, while not initiating necrosis, apoptosis, or autophagy [1].