SA-VA
Product Specifications
Target
Ephrin Receptor, VEGFR, Apoptosis, PROTACs
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, PROTAC, Apoptosis
Bioactivity
SA-VA, an intracellular self-assembled PROTAC featuring azide and alkyne groups, selectively degrades VEGFR-2 and EphB4 proteins within U87 cells. This compound undergoes in situ conversion to active PROTAC via a copper-catalyzed click reaction utilizing endogenous copper present in tumor tissues. Additionally, SA-VA induces apoptosis and arrests cell cycle progression in the S phase [1].
Molecular Formula
C50H53ClF3N11O7S
Molecular Weight
1044.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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