FD1024
Product Specifications
CAS Number
1422456-47-0
Target
Pim
Related Pathways
JAK/STAT signaling, Chromatin/Epigenetic
Bioactivity
FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively. It demonstrates significant antiproliferative effects on several AML cell lines, with IC50 values of 0.16 μM for EOL-1, 0.12 μM for MV-4-11, 1.05 μM for KG-1, and 1.39 μM for MOLM-16. Additionally, FD1024 has shown antitumor efficacy in murine models [1].
Smiles
FC1=C(C(F)=CC=C1)C2=NC(C(NC=3C(O[C@H]4CC[C@H](N)CC4)=CC=NC3)=O)=CS2
Molecular Formula
C21H20F2N4O2S
Molecular Weight
430.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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