Antileishmanial agent-19
Product Specifications
Target
Parasite
Related Pathways
Microbiology/Virology
Bioactivity
Compound F27 (Antileishmanial agent-19) is an antileishmanial compound effective against L. donovani promastigotes, demonstrating an IC50 of 3.39 μM. It functions by inhibiting the Leishmania prolyl-tRNA synthetase and disrupting the host PI3K/Akt/CREB axis-mediated IL-10 secretion. Additionally, Compound F27 promotes autophagy-mediated apoptosis in L. donovani promastigotes and has been shown to reduce parasite burden in L.d-infected animals [1].
Molecular Formula
C22H18N4O3
Molecular Weight
386.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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