HL23
Product Specifications
CAS Number
1448355-15-4
Target
Others|||HDAC
Related Pathways
Others|||DNA Damage/DNA Repair|||Chromatin/Epigenetic
Bioactivity
HL23 is a histone deacetylase (HDAC) inhibitor that effectively targets hepatocellular carcinoma (HCC) . It promotes acetylation at the TXNIP promoter and increases TXNIP expression, modulating potassium channel activity and inducing TXNIP-dependent potassium deficiency. Additionally, HL23 impedes HCC progression and spread, demonstrating greater potency when combined with Sorafenib than the Sorafenib and Vorinostat duo [1].
Smiles
O(C(=O)C1=CC=CC=C1)C2=C3C=4[C@](CC=5C=C(C(OC)=CC5)OC=6C=CC(C[C@]7(C8=CC(O3)=C(OC)C=C8CCN7C)[H])=CC6)(N(C)CCC4C=C2OC)[H]
Molecular Formula
C44H44N2O7
Molecular Weight
712.83
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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