Anticancer agent 154
Product Specifications
Target
Reactive Oxygen Species, Apoptosis, Ferroptosis
Related Pathways
Immunology/Inflammation, NF-κB, Apoptosis, Metabolism
Bioactivity
Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causes mitochondrial damage, and promotes cell apoptosis and DNA damage. It triggers ferroptosis by depleting GSH, diminishing GPX4 expression, and escalating lipid peroxidation. Additionally, it effectively suppresses the proliferation of various cancer cells (HT29, H1975, A549, and MCF-7) with IC50 values ranging from 1.0 to 1.9 μM [1].
Molecular Formula
C22H23N5O2
Molecular Weight
389.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
044178-AP 200 µL
ZNF286A, ID (ZNF286A, KIAA1874, ZNF286, Zinc finger protein 286A) (AP) discontinued
Sign In for Pricing
View Details K3442107 1.0 µg DNA
Deb1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
Sign In for Pricing
View Details