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ER degrader 7

Product Specifications

CAS Number

2922929-63-1

Target

Others, Estrogen Receptor/ERR, Microtubule Associated

Related Pathways

Others, Endocrinology/Hormones, Cytoskeletal Signaling

Bioactivity

ER degrader 7 (Compound 35t) is a selective degrader of both ERα and ERβ and functions as a tubulin polymerization inhibitor. It inhibits cell viability with IC50 values of 0.06 μM for MCF-7, 2.56 μM for T47D, 15.84 μM for MCF-10A, 1.59 μM for LCC2, 1.67 μM for T47D D538G, and 1.37 μM for T47D Y537S cells. Additionally, ER degrader 7 demonstrates efficacy in suppressing breast cancer tumor growth [1].

Smiles

S(N(CC(F)(F)F)C1=C(F)C=CC=C1)(=O)(=O)C2C3C(=C(C(O3)C2)C4=CC=C(O)C=C4)C5=CC=C(NC(CCCCC[Se]C#N)=O)C=C5

Molecular Formula

C33H31F4N3O5SSe

Molecular Weight

736.63

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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