FD2056
Product Specifications
CAS Number
2685870-87-3
Target
PI3K
Related Pathways
PI3K/Akt/mTOR signaling
Bioactivity
FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3K?, PI3K?, PI3K?, and PI3K?, respectively. Additionally, it exhibits inhibitory effects on CDK2-CyclinA2 and CDK4-CyclinD3 with IC50s of 115.95 nM and 2782.15 nM. FD2056 effectively inhibits the proliferation of various breast cancer cell lines, such as MDA-MB-231, MDA-MB-468, and MCF-7, with IC50s of 1.06 ?M, 0.04 ?M, and 1.40 ?M, respectively. The compound also promotes apoptosis in cancerous cells and has been shown to suppress tumor growth [1].
Smiles
NC1=CC(C=2C=3C(NC2)=NC=C(C3)C=4C=C(NS(=O)(=O)C5=CC=CC=C5)C(Cl)=NC4)=CC=N1
Molecular Formula
C23H17ClN6O2S
Molecular Weight
476.94
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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