Antiproliferative agent-34
Product Specifications
CAS Number
2910858-34-1
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling
Bioactivity
Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT. Additionally, it inhibits JAK2, ROS1, FLT3, FLT4, and PDGFR? with respective IC50s of 30.93 nM, 106.90 nM, 108.00 nM, 226.60 nM, and 42.53 nM. In normoxic conditions, it suppresses the proliferation of H1975 and HCC827 cells with IC50 values below 40 nM, while under hypoxic conditions, its potency increases 4-6 fold, yielding IC50 values less than 10 nM [1].
Smiles
O=[N+](C1=NC=CN1CCOCCOC(C=C2NC3=NC=CC(C(C4=CC=CC=C45)=CN5C)=N3)=C(C=C2)OC)[O-]
Molecular Formula
C27H27N7O5
Molecular Weight
529.55
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/123792164189634689/T79368
Available Sizes
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